منابع مشابه
Stored iron and vascular reactivity.
Zheng et al 1 report that volunteer blood donors with a high donation frequency have significantly greater flow-mediated dilation than low frequency donors. Iron status among the frequent donors approximated a state of iron depletion by assessment of conventional iron markers. The study provides important support for the “iron hypothesis,” which suggests a protective effect of iron depletion, i...
متن کاملTestosterone and vascular reactivity.
The mechanisms by which male sex hormones modulate cardiovascular function are a subject of contemporary interest. Several lines of evidence indicate that androgens can exert acute vasorelaxing effects. On the other hand, chronic exposure to androgens has been shown to promote increases in blood pressure and compromise renal function. In the present issue of Clinical Science, Malkin and co-work...
متن کاملIron accelerates hemoglobin oxidation increasing mortality in vascular diseased guinea pigs following transfusion of stored blood.
Non-transferrin-bound iron (NTBI) and free hemoglobin (Hb) accumulate in circulation following stored RBC transfusions. This study investigated transfusion, vascular disease, and mortality in guinea pigs after stored RBC transfusion alone and following cotransfusion with apo-transferrin (apo-Tf) and haptoglobin (Hp). The effects of RBC exchange transfusion dose (1, 3, and 9 units), storage peri...
متن کاملMembrane function and vascular reactivity.
This communication examines the possibility that nitric oxide (NO) production by endothelial cells results from changes in cell membrane fluidity. Lysophosphatidylcholine (LPC) alters fluidity of the endothelial cell membranes causing vascular relaxation. Through membrane alterations LPC influences function of a number of membrane receptors and modulates enzyme activity. As a result of detergen...
متن کاملVascular reactivity in hypertension.
IN ESTABLISHED human hypertension, there has never been any real doubt that the baroreceptor mechanisms remain active, hut regulate the arterial pressure to a new high level. The upward setting of these baroreeeptors occurs not only in essential hypertension but also in hypertension secondary to renal disease of various sorts. There is also evidence from the effects of ganglion blocking drugs t...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2005
ISSN: 1079-5642,1524-4636
DOI: 10.1161/01.atv.0000174124.20147.22